National Postdoctoral Association Career Center Director
Oncology, MD Clinician Lead- Early Clinical Development
P Director Oncology, MD Clinician Lead- Early Clinical
As the Director Oncology, MD Clinical Lead-Early Clinical
Development for the Boulder Research and Development Unit of
Pfizer, you will be responsible for establishing the initial
clinical development plan for one or more targeted, small molecule
anti-cancer therapies, from the discovery of lead compounds through
clinical proof-of-concept. You will serve as the primary clinical
resource for internal and external stakeholders, including
scientists, operations specialists, regulatory experts, KOLs and
Your key responsibility will be to design, execute and be
accountable for innovative and seamless first-in-human clinical
trials that ensure the safety of enrolled patients and enable a
clear and efficient assessment of PK, toxicity and preliminary
clinical activity in clearly defined patient populations with unmet
Your studies should support an initial regulatory approval,
should the clinical activity and specific medical need be
sufficient; clearly identify the appropriate patient population(s)
for further study in later-stage trials; and enable a data-driven
"No Go" decision if the risk: benefit ratio is unfavorable.
In this role, you will work alongside chemists and biologists
comprising one of the leading cancer drug development teams
anywhere, responsible for the creation of multiple first- and
best-in-class small molecule cancer medicines.
The Boulder R & D unit is located in Boulder, CO, a mecca for
the biomedical sciences and routinely selected for "top ten" lists
for recreation, culture, health and overall quality of life.
While previous experience with early phase clinical trials is
helpful, we are especially interested in clinicians and
clinician-scientists at any stage of their careers driven by
curiosity, enthusiasm, a desire to make a difference and a growth
mindset. By applying. critical thinking, diligence, clear
communication and a willingness to gain new expertise, make
mistakes and learn from them, you will contribute significantly to
patients fighting their cancers while developing your passion for
the entire drug development process.
Provides leadership on the clinical aspects of the development
program. This includes formulating the overall clinical development
plan, designing key study documents (e.g. protocols, IBs,
amendments, regulatory documents and SOPs); identifying key sites
for study participation; conducting data review, analysis and
interpretation of trials results; organizing and presenting at
advisory boards, investigator meetings and medical meetings; and
developing strong relationships with investigators and study
Accountable for safety across the study by real-time review of
individual patient safety data, performance of cumulative safety
review and timely communication about safety issues with the
internal safety risk team, investigators, study staff, IRBs and
Contributes clinical expertise at all stages of drug
development: identifies the critical unmet clinical needs for
pipeline candidates; determines the key questions to ask and how to
answer them directly through clinical trials; assembles and
analyzes safety, PK and efficacy data as it emerges; and
contributes to Go-No recommendations for the compound, including
recommendation to advance to FIH after review of the preclinical
package and involvement with transition to Phase III.
In collaboration with members of the development team, authors
and presents data at relevant team, strategy, governance, KOL,
regulatory and medical meetings; authors preclinical/clinical
sections of regulatory documents (Annual Reports, IND sections,
CSR, briefing books); and contributes to manuscripts for
Interfaces with key internal and external stakeholders:
discovery, safety sciences, statistics, PK/PD, marketing,
regulatory, outcomes research, development operations, governance,
external experts, regulators, investigators and study staff.
Participates in CRO diligence and selection; works
collaboratively with the study team and CRO to develop the EDC and
manage the trial; develops and delivers protocol training for
investigator site(s), Pfizer personnel, and CRO staff.
In conjunction with study team, responsible for the on-time and
within-budget execution of protocols
May have functional responsibility for other clinicians assigned
to the project and may supervise and develop other colleagues.
May act as the clinical representative in in-licensing
activities such as due diligence reviews and reports.
"Candidate demonstrates a breadth of diverse leadership
experiences and capabilities inclcuding: the ability to influence
and collaborate with peers, develop and coach others, oversee and
guide the work of other colleagues to achieve meaningful outcomes
and create business impact."
MD with demonstrated depth and breadth of knowledge and
experience in clinical care and research in the academic, clinical
practice and/or industry setting. D.O. degrees who demonstrate
these qualities will also be considered.
Prior specialized training in Medical Oncology with Board
Certification is desirable; other relevant, specialized medical
training (e.g. surgical oncology, infectious disease, critical
care) will be considered.
Broad clinical knowledge and an ability to apply it from
bench-to-bedside and back.
Curiosity and a willingness to try new things.
Understanding of related disciplines (e.g. biology, chemistry,
translational medicine, biostatistics, regulatory, pharmacology),
or a willingness to achieve understanding through independent
Demonstrated scientific thinking and writing skills and good
Demonstrated leadership, ability to work collaboratively, enjoys
and able to adapt to a fast-paced and changing environment.
Other Job Details:
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Pfizer reports payments and other transfers of value to health
care providers as required by federal and state transparency laws
and implementing regulations. These laws and regulations require
Pfizer to provide government agencies with information such as a
health care provider's name, address and the type of payments or
other value received, generally for public disclosure. Subject to
further legal review and statutory or regulatory clarification,
which Pfizer intends to pursue, reimbursement of recruiting
expenses for licensed physicians may constitute a reportable
transfer of value under the federal transparency law commonly known
as the Sunshine Act. Therefore, if you are a licensed physician who
incurs recruiting expenses as a result of interviewing with Pfizer
that we pay or reimburse, your name, address and the amount of
payments made currently will be reported to the government. If you
have questions regarding this matter, please do not hesitate to
contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and
conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Pfizer also complies with all
applicable national, state and local laws governing
nondiscrimination in employment as well as work authorization and
employment eligibility verification requirements of the Immigration
and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Job ID: 54485431
Position Title: Director Oncology, MD Clinician Lead- Early
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