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(Senior) Principal Scientist, Enzymology

Company: Lever
Location: Boulder
Posted on: January 8, 2022

Job Description:

(Senior) Principal Scientist, Enzymology Cogent Biosciences is a biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent's lead therapeutic candidate, CGT9486 (formerly known as PLX9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. Cogent Biosciences is growing! This position would be an integral part of our newly formed research team in Boulder, CO. This Senior/ Principal Scientist will be responsible for the management, design, and execution of enzymatic assays to support target validation and project advancements in close collaboration with other Discovery Biology team members. The ideal candidate will have a strong understanding of mechanistic enzymology as well as previous experience with small molecule drug development programs. The candidate will use this experience and knowledge in the field to provide strategic input to target identification and validation strategies. This individual will both conduct and oversee enzymology activities, and work with a multi-disciplinary team with the common goal of bringing forward innovative cancer therapies. - What You Will Do:

  • Lead efforts in identifying and validating potential therapeutic candidates
  • Provide a high level of enzymology expertise through familiarity with current scientific literature and mentorship of colleagues
  • Lead and execute -enzymology -experiments to characterize and validate novel targets
  • Continue advancement of drug development efforts through discovery and clinical programs
  • Proactively investigate new and innovative technologies to improve target validation and advance discovery projects
  • Collaborate with a cross-functional and interactive team
  • Organize and manage experiments and data coming from external CROs What You Will Bring:
    • Ph.D. in Mechanistic Enzymology or related field with 5+ years of relevant industry experience or BS/MS with 15+ years of relevant experience
    • Extensive experience in characterization of small molecule protein interactions and in the design and hands-on implementation of standard enzymatic and biophysical techniques to address key project goals
    • Demonstrated success in working with cross-functional teams, preferably in a drug discovery setting.
    • Ideal candidate can develop novel ideas and technologies and is eager to learn
    • Excellent interpersonal, written, and verbal communication skills
    • Base Salary Range $ 108,583 - $149,855
    • Bonus Target %12.5 of Base Salary Our Locations Cambridge, MA: Our Boston office is located within walking distance of the Alewife T station in Cambridge, MA. Our space includes an open office layout designed for collaboration. Free access is provided for both on-site parking and gym facilities in the building. We are in close proximity to leading academic institutions like MIT and Harvard and to potential pharmaceutical and biotech partners. This unique location allows for a high level of energy and intellectual exchange within and among fast growing early stage companies. Boulder, CO: We are in the process of building a second location in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor. Our CEO is based full-time in this location, which will serve as the future home of Cogent's discovery research organization. Our Offer To You To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), unlimited time-off, a 401(k) plan, and commuter/parking benefits.

Keywords: Lever, Boulder , (Senior) Principal Scientist, Enzymology, Other , Boulder, Colorado

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