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Scientist, Drug Metabolism and Pharmacokinetics (DMPK)

Company: Edgewise Therapeutics
Location: Boulder
Posted on: June 25, 2022

Job Description:

Position Summary:Edgewise is looking for a self-motivated scientist who wants to advance drug discovery programs into the clinic. You will have an opportunity to be a functional area lead developing novel sarcomere targeting small molecule modulators in rare skeletal and genetic cardiac diseases. We are looking for a teammate who shares our passion for drug discovery and seeks a scientifically rigorous and collaborative environment. Role: You will be the functional area representative for DMPK on multidisciplinary discovery project teams. As a member of the discovery team, you will work cross-functionally and as needed with external CROs. The successful candidate will actively contribute to the generation and assessment of study results that support our discovery efforts.Primary Responsibilities: Coordinate in vitro ADME and in vivo pharmacokinetic studies with our CRO partners.

  • Analysis, interpretation, integration, and reporting of pharmacokinetic data and pharmacokinetic/pharmacodynamic (PK/PD) data to support discovery/preclinical projects.
  • Participate and contribute to discovery/preclinical development project teams.
  • Assist in design and execute preclinical studies to understand ADME characteristics of drug candidates.
  • Ability to independently review and summarize results.
  • Clear communication of ADME/PK results at project team meetings and other meetings as needed.
  • Author regulatory documents to support FIH programsRequirements:Education, Skills and Experience
    • Ph.D. (or equivalent degree plus years' experience) in Pharmacokinetics, Pharmacology, Pharmaceutics, Engineering or other relevant field with > 3 years of experience in the biopharmaceutical industry
    • Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles.
    • Proficient knowledge of ADME/DMPK assays and assessments used in drug discovery and drug development (e.g., in vitro stability, DDI, preclinical pharmacokinetics, and in vitro and in vivo correlations, etc.).
    • Experience in PK and or PK/PD analysis using WinNonlin.
    • Experience in serving on project teams in early discovery.
    • Previous experience working with external CROs.
    • Working knowledge of IND and regulatory submissions is helpful.
    • Articulate, open communicator (both oral and written) with the ability to analyze, interpret and present data in a clear mannerSalary range: $80,000 - $140,000 title and compensation commensurate with experience.If interested in this position, please apply at https://edgewisetx.com/join-our-team/ or apply via LinkedIn.Edgewise is proud to be an equal opportunity employer. Our offers are contingent on background check and education verification.Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes.

Keywords: Edgewise Therapeutics, Boulder , Scientist, Drug Metabolism and Pharmacokinetics (DMPK), Other , Boulder, Colorado

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